Towards spatial comprehensive three-dimensional liquid chromatography: A tutorial review
نویسندگان
چکیده
In spatial comprehensive three-dimensional chromatography (3D-LC) components are separated within a separation space that can lead to unprecedented resolving power, in terms of peak capacity and peak-production rate. The maximum is the product capacities achieved individual dimensions when orthogonal retention mechanisms incorporated. parallel development second- third-dimension stages overcomes fundamental limitation conventional multi-dimensional approaches, which sampled fractions analyzed sequentially. General considerations for chip design discussed possibilities prospects establish 3D-LC analysis presented.
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ژورنال
عنوان ژورنال: Analytica Chimica Acta
سال: 2021
ISSN: ['0003-2670', '1873-4324']
DOI: https://doi.org/10.1016/j.aca.2020.12.032